Joint ingredient shown to work in only five days

The revolution in joint-health supplements continues with innovative, fast-acting AprèsFlex brand frankincense.

Todd Runestad, Content Director,

August 17, 2022

3 Min Read
Joint ingredient shown to work in only five days

Move over, slow-acting glucosamine. Consumers want relief from joint pain in days, not months, and an enhanced-bioavailability frankincense ingredient has been shown to provide joint-pain relief in only five days.  

The ingredient, branded AprèsFlex, is a next-generation 5-LOXIN (Boswellia serrata, or frankincense) with higher bioavailability. 5-LOXIN, sourced from supplier PLT Health Solutions, is the fast-acting ingredient used in market-leading supplement brand, Osteo BiFlex, which calls it 5-LOXIN Advanced as an exclusive on its bottles.  

In the third human study on AprèsFlex, results were consistent with previous studies in terms of time to joint comfort efficacy and dose.  

The significance of this study is that it is the second double-blind, placebo-controlled trial that shows results as soon as five days at a 100 mg/day dose. In perspective, dose size for glucosamine and chondroitin is 1,500 mg and 1,200 mg, respectively, and efficacy starts in generally about six to eight weeks—that’s two supplement bottles’ worth.  

This study will give more risk-averse consumer products companies more confidence in messaging five days to relief. Most people reach for non-steroidal anti-inflammatories when joints ache, and then grin and bear it for months before glucosamine supplements kick in. The five-day solution thus is an important value in this space. 

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“When it comes to mobility, there can be a disconnect between what consumers want and what existing solutions deliver,” Seth Flowerman, President & CEO of PLT Health Solutions. “Too often, natural joint and muscle health solutions require large doses that take weeks or even months to show improvements—and the science backing these ingredients doesn’t support what consumers are looking for.” 

AprèsFlex is a patented, synergistic combination of two proprietary extracts derived from  Boswellia serrata  gum resin, launched in 2013. The oral bioavailability of acetyl-11-keto-beta-boswellic acid (AKBA) from AprèsFlex is significantly higher than that of other commercially available Boswellia extracts, which allows for a lower daily dose, with enhanced efficacy. In joint health products, AprèsFlex is used often as a standalone ingredient or in conjunction with other ingredients to power some of the best-known joint health consumer brands in the world. It has been the subject of seven pre-clinical studies and three published human clinical trials. 

Study details 

Specifically, researchers in India examined the efficacy of AprèsFlex in the management of joint comfort and function in a randomized, double-blind, placebo clinical trial. Sixty-seven subjects received either 100 mg/day of AprèsFlex or a matching placebo for 30 days. Measurements included The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Score (VAS), the Lequesne algofunctional index (LFI) and six different blood biomarkers. Measurements were done on days 0, 5 and 30.  

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The study showed that AprèsFlex provided significant improvement (p<0.05) in all pain and physical function scores at five days compared to placebo. Post-trial, VAS, LFI, WOMAC pain, WOMAC stiffness, WOMAC function, and total WOMAC scores decreased in the AprèsFlex group by 45%, 40.9%, 44.4%, 66.3%, 44.4%, and 48%, respectively.  

Beyond joint comfort and function improvements, AprèsFlex was also shown to offer statistically significant positive changes on biological markers associated with joint health and inflammation metabolism, including TNF-alpha, C-Reactive Protein (CRP), and Interleukin-6 (IL-6). It was also shown to significantly inhibit matrix metalloproteinase (MMP-3), an enzyme that breaks down cartilage, collagen, and connective tissue.  

Previous studies with AprèsFlex showed 56% reduction in pain scores at 30 days. A similar study with AprèsFlex showed a 69% reduction in pain scores at 90 days. 

According to Jeremy Appleton, N.D., director of medical and scientific affairs for PLT, this new study confirms previous results with AprèsFlex and should give innovators of joint health and mobility products confidence in the fast-acting messaging supported by the science.  

“We now have three double-blind placebo-controlled clinical trials that validate the efficacy of AprèsFlex, and two demonstrating improvements as early as five days, at a low dose,” he said. “These outcomes support our customers’ “fast-acting” claims for their products containing AprèsFlex.” 

About the Author(s)

Todd Runestad

Content Director,, Natural Products Insider

Todd Runestad has been writing on nutrition science news since 1997. He is content director for and Natural Products Insider digital magazines. Other incarnations: supplements editor for, Delicious Living!, and Natural Foods Merchandiser. Former editor-in-chief of Functional Ingredients magazine and still covers raw material innovations and ingredient science.

Connect with me here on LinkedIn.


Todd writes about nutrition science news such as this story on mitochondrial nutrients, innovative ingredients such as this story about 12 trendy new ingredient launches from SupplySide West 2023, and is a judge for the NEXTY awards honoring innovation, integrity and inspiration in natural products including his specialty — dietary supplements. He extensively covered the rise and rise and rise and fall of cannabis hemp CBD. He helps produce in-person events at SupplySide West and SupplySide East trade shows and conferences, including the wildly popular Ingredient Idol game show, as well as Natural Products Expo West and Natural Products Expo East and the NBJ Summit. He was a board member for the Hemp Industries Association.

Education / Past Lives

In previous lives Todd was on the other side of nature from natural products — natural history — as managing editor at the Denver Museum of Nature & Science. He's sojourned to Burning Man and Mount Everest. He graduated many moons ago from the State University of New York College at Oneonta.


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