Probiotics for Weight Loss?

One study indicates yes, according to Maylin Rodriguez-Paez, RN, Life Extension's social media content specialist.

Maylin Paez, Maylin Paez

July 1, 2014

3 Min Read
Probiotics for Weight Loss?

Probiotics can help your stomach feel better, but can they “slim” your stomach too? It’s been hypothesized that gut bacteria influence weight. The overuse of antibiotics has been linked to weight gain, and studies have shown differences in the flora of obese and thin animals.1  Researchers in Quebec wanted to test this hypothesis by giving overweight people probiotics, and the results were somewhat of a surprise. Ready?

Women Taking Probiotics Lost Weight

Scientists recruited 125 obese people and randomly split them into two groups. One group was given a probiotic containing Lactobacillus rhamnosus. The other group received a placebo. All subjects participated in a weight loss plan for 12 weeks followed by a weight-maintenance period for another 12 weeks. 

After the 12-week weight loss period, the women in the treatment group lost an average of 9.7 pounds, compared to 5.7 pounds in the placebo group. No significant weight loss changes were seen between the men in the placebo and treatment group. 

What’s even more interesting is that after the maintenance period, the women in the treatment group continued to lose weight and body fat. On the other hand, the women in the placebo group experienced opposite effects.2

Probiotics Lower Leptin and Block Inflammation

Hunger hormones and inflammation play key roles in obesity. It’s not just about the calories you consume and burn off. 

In the Quebec study, women taking the probiotics had lower levels of circulating leptin, a hunger hormone with appetite modulating effects. Leptin acts as a switch in your brain to turn hunger signals off, and it reduces body fat. Obese people tend to have higher levels of leptin in their blood. 

Inflammatory compounds block leptin receptor sites, making the body “resistant” to its effects. Consequently, the body responds by producing more leptin. This creates a vicious cycle of inflammation and obesity. Alternatively, decreased leptin levels indicate a lessening of “leptin resistance.” 

Probiotics lower intestinal permeability. They keep the intestinal barrier strong, which, according to the Quebec researchers, could help keep inflammatory compounds from entering the bloodstream.

Eat Probiotic-Rich Foods and Supplement

Even if you’re not trying to lose weight, make an effort to obtain more probiotics in your diet. It can make a big difference in your health. 

The typical Western diet can deplete the good bacteria in your gut. Antibiotics, excessive hygiene, and aging can cause further imbalances. Once the good bacteria are destroyed, bad bacteria quickly multiply and open the door for health problems. 

Not sure where to start once you’re away from the R&D side of things? Here are some foods to take note of: 

  • Yogurt

  • Soft cheeses

  • Natto

  • Sourdough bread

  • Pickled/fermented vegetables

  • Kefir

  • Kombucha

  • Tempeh

  • Kimchi

  • Miso

  • Sauerkraut

In addition to eating more of these foods, consider taking a probiotic supplement. It’s the easiest way to ensure you’re getting enough healthy bacteria into your body. You’ll find a variety of pills on the market with varying strengths, but aim for a product that offers several billion friendly bacteria daily.


  1. Clin Microbiol Infect. 2013 Apr;19(4):305-13.

  2. Br J Nutr. 2013 Dec 3:1-13.


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