December 6, 2004
GliSODin Protects Against DNA Damage
Scientists testedthe hypothesis that a new formulation consisting of wheat gliadin chemicallycombined with a vegetal preparation of superoxide dismutase (SOD) (asGliSODin®, supplied by Morristown, N.J.- based P.L. Thomas & Co. Inc.)prevents hyperbaric oxygen (HBO)-induced oxidative cell stress. The prospective,double blind, randomized, placebocontrolled study, published in FreeRadical Research (9:927-32, 2004), involved 20 healthyvolunteers. Each participant was exposed to 100 percent oxygen for a total of 60minutes. DNA strand breaks (tail moments) were determined using the alkalineversion of the comet assay. Whole blood concentrations of reduced (GSH) andoxidized (GSSG) glutathione and F2- isoprostanes, SOD, glutathione peroxidase(GPx) and catalase (Cat) activities and red cell malondialdehyde (MDA) contentwere determined.
After HBO exposure, the tail moment and isoprostane levelswere significantly lower in the group that received the vegetal formulation.Neither SOD and Cat nor GSH and GSSG were significantly affected by thispreparation or HBO exposure. By contrast, blood GPx activity, which tended to belower in the SOD-group already before the HBO exposure, was significantly lowerafterwards. The researchers concluded the orally effective SOD-wheat gliadinmixture can protect against DNA damage, which coincided with reduced bloodisoprostane levels, and may therefore be used as an antioxidant.
These findings support the body of evidence behind GliSODinsbenefits, a statement from P.L.Thomas read.GliSODins ability to promoteSOD, catalase and glutathione peroxidase, the powerful cellular antioxidantsproduced by our bodies, clearly make this a desirable dietary supplement, aswell as a powerful addition to antioxidant and antiinflammatory formulations.
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