Chondroitin Adulteration Still Rampant

Experts maintain ingredient suppliers are substituting chondroitin with cheaper substances that are often ending up on store shelves across America.

Josh Long, Associate editorial director, Natural Products Insider

February 5, 2014

3 Min Read
Chondroitin Adulteration Still Rampant

ChromaDex operates a third-party laboratory that tests for chondroitin to ensure it is consistent with a supplier's claims. Frank Jaksch, CEO of ChromaDex in Irvine, CA, said more than half the samples tested fail.

Even though ChromaDex has been testing chondroitin for a decade, and FDA's years-old cGMPs (current good manufacturing practices) require manufacturers of dietary supplements to test their ingredients, Jaksch said failure rates have remained the same.

Experts maintain such failures are symptomatic of a widespread problem: ingredient suppliers are substituting chondroitin with cheaper substances that are often ending up on store shelves. For instance, Consumer Reports revealed in its October 2013 issue that seven of 16 glucosamine/chondroitin supplements it tested did not contain their claimed level of chondroitin.

Chondroitin comes into the United States from as far away as India and China. While U.S. manufacturers of dietary supplements have an obligation under FDA's cGMPs to test their ingredients, experts note certain testing methods are unreliable.

For instance, Jaksch contends a common testing method known as cetyl pyridinium chloride (CPC) titration is incapable of distinguishing between chondroitin and a similar polysaccharide such as inulin. Others pointed out similar flaws in the CPC titration method.

U.S. Pharmacopeia Convention, the global health organization, noted its monograph, which uses CPC titration, "contains several different tests that complement each other to characterize the ingredient's quality" and that requirements for every test in its monograph must be satisfied to comply with USP standards.

"The assay value alone tells only an incomplete story because to be labeled 'USP,' the chondroitin sulfate sodium must also comply with the other tests provided in the USP monograph (for example, electrophoresis on cellulose acetate membrane, IR identification test and optical rotation)," the health organization stated.

Weiguo Zhang, president and COO of Synutra International Inc., recommended using CPC testing in combination with another method (cellulose acetate membrane electrophoresis).

Zhang told Natural Products INSIDER that "the two methods complement each other to keep the CPC value true and the material pure."

Xiaoming (Sandy) Chien, Ph.D., vice president of Innovative Products at HORN Nutraceuticals, said there are a number of alternative methods to test chondroitin sulfate, including carbazole, reversed phase HPLC and most recently and enzymatic HPLC.

"One of the [testing] challenges is the nature of the material itself," Chien said in a written statement to INSIDER. "Chondroitin sulfate has broad molecular weight variation due to its various sources, its poor UV absorbance, and strong ionic nature. The other challenge includes impurities and adulterants in chondroitin sulfate materials."

Experts also acknowledge some testing methods are more expensive than others, giving companies an incentive to opt for cheaper methods that may be less reliable.

USP's testing method "has opened up windows for sophisticated adulterants," Chien said.

U.S. Pharmacopeia Convention denied that this is the case, declaring that "there is little room for adulteration" if "all of the test methods required in the USP chondroitin sulfate sodium monograph are properly performed."  

Zhang cited a number of reasons for chondroitin's adulteration problem including the following: pricing pressure pushes industry to cut cost; lack of regulatory enforcement across nations and jurisdictions; lack of effective testing methodologies; substandard sourcing practices; and purposefully using less chondroitin than the label claim.

While Jaksch has not observed harmful adulterants used in chondroitin, he pointed out intentional adulteration still constitutes fraud because consumers are not buying what they were promised.

"A majority of what we see is intentional adulteration," he said.

Read more about the joint health industry's challenges and considerations in INSIDER's Joint Health Digital Issue.

About the Author(s)

Josh Long

Associate editorial director, Natural Products Insider, Informa Markets Health and Nutrition

Josh Long directs the online news, feature and op-ed coverage at Natural Products Insider, which targets the health and wellness industry. He has been reporting on developments in the dietary supplement industry for over a decade, with a focus on regulatory issues, including at the Food and Drug Administration.

He has moderated and/or presented at industry trade shows, including SupplySide East, SupplySide West, Natural Products Expo West, NBJ Summit and the annual Dietary Supplement Regulatory Summit.

Connect with Josh on LinkedIn and ping him with story ideas at [email protected]

Education and previous experience

Josh majored in journalism and graduated from Arizona State University the same year "Jake the Snake" Plummer led the Sun Devils to the Rose Bowl against the Ohio State Buckeyes. He also holds a J.D. from the University of Wyoming College of Law, was admitted in 2008 to practice law in the state of Colorado and spent a year clerking for a state district court judge.

Over more than a quarter century, he’s written on various topics for newspapers and business-to-business publications – from the Yavapai in Arizona and a controversial plan for a nuclear-waste incinerator in Idaho to nuanced issues, including FDA enforcement of the Dietary Supplement Health and Education Act of 1994 (DSHEA).

Since the late 1990s, his articles have been published in a variety of media, including but not limited to, the Cape Cod Times (in Massachusetts), Sedona Red Rock News (in Arizona), Denver Post (in Colorado), Casper Star-Tribune (in Wyoming), now-defunct Jackson Hole Guide (in Wyoming), Colorado Lawyer (published by the Colorado Bar Association) and Nutrition Business Journal.

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