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Alpha lipoic acid for healthy aging

Research shows alpha lipoic acid helps reduce oxidative stress commonly associated with aging.

In a time where antioxidants are essential, consumers are looking for the right ingredient to combat free radicals. Known as thioctic acid, alpha lipoic acid is generated through small amounts in the mitochondria—otherwise known as “the powerhouse of the cell.” One study found that “As an antioxidant, [alpha lipoic acid] directly terminates free radicals, chelates transition metal ions (e.g., iron and copper), increases cytosolic glutathione and vitamin C levels, and prevents toxicities associated with their loss.”1 Also known to help with the aging process, another study found ALA helps lower oxidative stress associated with aging.2

In addition, according to Clinical Nutrition, ALA plays a key part in boosting energy production, as it helps the physiological responses to stress.3 As aging occurs, the body is not capable of maintaining the same level of cellular energy production. The Clinical Nutrition study evaluated the efficacy of carnitine, a mitochondrial metabolite, and lipoic acid. The research indicated that an age-dependent decrement in the levels of the TCA cycle enzymes and electron transport chain complexes, in which supplementation of carnitine (300 mg/kg bw/d) and lipoic acid (100 mg/kg bw/d) for 30 days brought the activities close to normal levels. This suggested that alpha lipoic acid helped reverse the age-related decline.

An additional study found that added with L-carnitine, alpha lipoic acid reduced oxidative stress and improved mitochondrial function.4 In the double blind, crossover study, researchers examined the effects of alpha lipoic acid with acetyle L-carnitine treatment on vasodilator function and blood pressure in 36 subjects for eight weeks compared to placebo. The results indicated that active treatment increased brachial artery diameter by 2.3 percent and reduced systolic blood pressure for the entire group. Moreover, there was a dramatic effect in the subgroup with blood pressure above the median, and in the subgroup with the metabolic syndrome. This strongly indicated alpha lipoic acid’s effect on blood pressure and endothelia function in the brachial artery.

As an important part of cellular production, alpha lipoic acid plays a profound impact on oxidative stress. Indeed, the right ingredient to combat free radicals could be Alpha lipoic acid—and helpful ingredient to provide consumers a long and healthy life.

Born in a small town in South Texas, Rivera has had a successful experience as a health professional, including being a personal trainer and sports coach.

References

  1. Smith A et al. “Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.” Curr Med Chem. 2004 May;11(9):1135-46.
  2. Suh J et al. “Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.” Redox Rep. 2005;10(1):52-60.
  3. Savida S et al. “Efficacy of leveo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging.” Clinical Nutrition, 2005, Oct;25(5) 794-800.
  4. McMackin C et al. “Effect of Combined Treatment With a-Lipoic Acid and Acetyl-L-Carnitine on Vascular Function and Blood Pressure in Patients With Coronary Artery Disease.” Journal of Clinical Hypertension, 2007, April;9 (4) 249-255
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