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Creating a softgel delivery system that fulfills the latest specifications and end-use requirements is a complex and highly challenging process. This whitepaper by Rousselot outlines key considerations to ensure gelatin is enhanced for softgel formulation, efficient gel production and optimal delivery of active ingredients, as well as the potential challenges contract development and manufacturing organizations (CDMOs) could face if the right gelatin is not selected. Additional insight includes the impact of factors such as ingredient compatibility, molecular weight and gelatin bloom on the quality and stability of softgel capsules.

  • Ultimately, the reason for developing a softgel is to effectively deliver active ingredients.
  • Softgel stability and crosslinking properties of the gelatin should be taken into consideration.
  • Factors such as gelatin type and processing conditions can impact the leakage risk of softgels.