NEM brand eggshell membrane has been shown to reduce pro-inflammatory cytokines in-vitro in mitogen-challenged, healthy human immune cells. The mechanism of action has been extended to in-vivo studies as well. The results of these studies were published in Modern Research in Inflammation (MRI 2014 Feb; 3(1) 19-25).
The in vivo studies were performed to evaluate the effects of NEM on pro-inflammatory and anti-inflammatory cytokines following oral administration in rats. The results showed substantial reductions of pro-inflammatory cytokines while having little effect on the anti-inflammatory cytokines. The initial studies in healthy rats demonstrated large reductions (up to 88 percent) in cytokines that occur later in the inflammatory cascade (MCP-1, MIP-1β, RANTES, VEGF). A follow-up study in inflammatory-challenged rats demonstrated significant reductions (40-44 percent) in IL-1β, a key primary mediator of inflammation.
We were pleased to find evidence that NEM® helps to maintain a normal inflammatory response in healthy animals. And the novel nature of this finding formed the basis for a patent (U.S. 8,580,315) that was recently granted for this same indication," said director of scientific and regulatory affairs for ESM Kevin J. Ruff, Ph.D.