Research Shows NEM Helps Maintain Normal Inflammatory ResponseResearch Shows NEM Helps Maintain Normal Inflammatory Response

New research on ESM Technologies' eggshell membrane ingredient, NEM has been released that explains how the product supports healthy joints.

NEM brand eggshell membrane has been shown to reduce pro-inflammatory cytokines in-vitro in mitogen-challenged, healthy human immune cells. The mechanism of action has been extended to in-vivo studies as well. The results of these studies were published in Modern Research in Inflammation (MRI 2014 Feb; 3(1) 19-25).

The in vivo studies were performed to evaluate the effects of NEM on pro-inflammatory and anti-inflammatory cytokines following oral administration in rats. The results showed substantial reductions of pro-inflammatory cytokines while having little effect on the anti-inflammatory cytokines. The initial studies in healthy rats demonstrated large reductions (up to 88 percent) in cytokines that occur later in the inflammatory cascade (MCP-1, MIP-1β, RANTES, VEGF).  A follow-up study in inflammatory-challenged rats demonstrated significant reductions (40-44 percent) in IL-1β, a key primary mediator of inflammation. 

We were pleased to find evidence that NEM® helps to maintain a normal inflammatory response in healthy animals.  And the novel nature of this finding formed the basis for a patent (U.S. 8,580,315) that was recently granted for this same indication," said director of scientific and regulatory affairs for ESM Kevin J. Ruff, Ph.D.