Natural Products Insider is part of the Informa Markets Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

Quatrefolic® Officially Joins Chinese Food Safety Law

Article-Quatrefolic® Officially Joins Chinese Food Safety Law

<p>With a publication date of October 20th 2017, Quatrefolic&reg; officially joins the &ldquo;Food Safety Law&rdquo; in China with a specific monograph that describes its quality (physical, chemical and microbiological) requirements.</p>

Press Release

With a publication date of October 20th 2017, Quatrefolic® officially joins the “Food Safety Law” in China with a specific monograph that describes its quality (physical, chemical and microbiological) requirements.

After the first positive assessment by the Ministry of Health of the People’s Republic of China (MOH), on early 2016, the use of Quatrefolic® as Food Nutritional Fortification Substance finally enters in force in China.

The published monograph defines dosage and intended use of Quatrefolic®, the 5-MTHF glucosamine salt, as a new active ingredient, introducing this innovative folate instead of the already known folic acid.

Quatrefolic® is the metabolically active folate that is not affected by the common impairments of folate metabolism since it does not require the complex absorption, metabolic and enzymatic steps that are required by folic acid. Contrary to folic acid, Quatrefolic® - being the metabolically active form of folate - is not influenced by the polymorphism of the MTHFR (methyltetrahydrofolate reductase) enzyme, a genetic defect with a high incidence in Chinese population.

In these part of the population folic acid is not effectively converted to the biologically active form 5-MTHF (methylfolate) due to the reduced enzymatic activity. Therefore, the beneficial effect of folic acid supplementation is not guaranteed in the folate deficiency related status of people, like Chinese(


In the recent years, a wide numbers of clinical studies have investigated the incidence of this polymorphism in China.  Of particular relevance, the very recent meta-analysis published in 2016 by Wang et al. where sixty-six studies were identified with a total of 92277 study participants, in 23 provinces in Mainland China.

The meta-analysis revealed that the frequencies of the MTHFR C677T allele and the 677TT genotype increased from lower values (5% and 17%, respectively) in Guangxi, to intermediate values (12% and 32%, respectively) in Anhui, to higher values (39% and 62%, respectively) in Shandong.

The frequency of the 1298C allele was found to be the lowest in northern China [18% (17%-19%)], intermediate in central China [18% (17%-19%)], and highest in southern China [28% (24%-31%)]. The mean frequency of the 1298C allele was 20% (18%-22%) (

Hide comments


  • Allowed HTML tags: <em> <strong> <blockquote> <br> <p>

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.