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A recently new published study (Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. J Biol Regul Homeost Agents. 2016) has investigated the efficacy of Quatrefolic<sup>®</sup> (400 mcg of Quatrefolic<sup>®</sup> plus B6, and B12 BID) in lowering homocysteine serum levels (HCys) versus a conventional vitamin supplementation (folic acid + vitamin B) in hypertensive subjects at low cardiovascular risk.