Recent studies on antioxidants, vitamin D, vitamin E, polyphenols, protein, selenium and CoQ10 show promise to heart health beyond traditional cholesterol and blood pressure indices.

Blake Ebersole, President

September 13, 2017

5 Min Read
Emerging Heart Health Ingredient Research

The essence or central point of an idea is often called the “heart" of the matter. Yet, among supplement categories, heart health is often forgotten about. This may come at the expense of our collective interest to live longer, healthier lives.

The job of the heart is to pump blood throughout the body, sending oxygen and nutrients to the rest of the body, and removing waste products. The heart pumps through the circulatory system, which has about 100,000 miles of blood vessels. Heart disease is still the No. 1 killer in the United States, and when the heart is compromised, so often is the rest of the body.

Dietary antioxidants are strongly linked to reductions in cardiovascular disease (CVD) risk. An abundance of evidence on the impact of antioxidant and nutrient intake on mortality from cardiovascular disease (CVD) has been published in recent years as a result of the National Health and Nutrition Survey (NHANES). For example, a lower intake of vitamins D and E was recently associated with high blood pressure, which is a major risk factor for CVD.

In a 2016 study published in the journal Circulation, intake of at least 16 g/d of whole grains was associated with a lower mortality rate from CVD. But heart health doesn’t always have to taste like cardboard. For example, consumption of three to four servings of antioxidant-rich chocolate per week was associated with a 10 percent lower rate of heart attack in Swedes.

Polyphenols and flavonoids are the most abundant antioxidants in our diets. They are created by plants to protect them from oxidative stress, and they benefit the human body in similar ways. Polyphenols also exhibit strong anti-inflammatory activities that support a heart-healthy diet. For example, a reduction in anti-inflammatory cytokines by polyphenols leads to reduced levels of atherosclerosis and blood lipids (especially bad low-density lipoprotein [LDL] cholesterol). Polyphenols also increase levels of protective markers, such as endothelial nitric oxide (NO), which helps blood vessels maintain their flexibility. The typical, often-found result from consumption of polyphenol-rich fruits and vegetables is a reduction in CVD markers.

Inflammation is more central to heart health than many previously thought. More recently, several studies have been published on the negative impact of pro-inflammatory diet, which can be measured by the Dietary Inflammation Index (DII). The Mediterranean diet, rich in fish, nuts and plant fats, is a prime example of a low-DII diet. Study after study supports the benefits of a low-DII diet on a number of endpoints, including reduced mortality from cardiovascular and brain ischemic events (heart attack and stroke) in addition to longer telomeres, chromosomal indicators of our biological age.

But when we think of the Mediterranean diet, many picture a nonagenarian drinking a glass of Chianti while slurping sardines from a can. But heart health and longevity isn’t just for old Italians anymore. Athletes and active people of all ages appear to benefit from heart-healthy diets. The availability of low-carbohydrate, plant-based whole foods are keys to maintaining optimal cardiovascular health. Getting more protein from plants instead of red meat has also been mentioned as a key tipping point toward better cardiovascular health for the entire population. Metabolic syndrome, which includes diabetes, obesity, CVD and other associated diseases, is a big problem for children in America. Plant-based diets and the elimination of highly processed foods are shown to be key to reducing metabolic syndrome, and therefore cardiovascular risk.

Part of the benefit of plant-based diets for cardiovascular health (aside from the lower sugar, lower carb, higher antioxidants and better fats) is the quality of protein. Several new protein sources are emerging as “better-for-you," more sustainable protein sources from hemp and pumpkin seed. Yet cow’s milk protein is still thought to be a superior protein, since it is more like breast milk than, say, a soybean or an almond. Efforts to improve cow’s milk, including high conjugated linoleic acid (CLA) grass-fed, antibiotic-free milk protein, are now being proven as a superior source of whey protein in the market.

It’s tempting for many marketers to jump on to the next trend, at the cost of forgetting about scientific foundations. While “fake news" ruled the zeitgeist of 2017, “fake nutrition" has always been somewhat of a part of our industry, defining a lot of the fads that have quickly come and gone. For physically active people, the weight loss and sports nutrition-driven craze for medium chain triglycerides (MCTs) from coconut and palm oil has been more driven by marketing than science. Although MCT and other saturated fats may be used by the brain as fuel, and could be useful for epilepsy and extreme weight loss, the benefits of a ketogenic, very-low-carb, calorie-restricted diet fat for long-term health has been called into question by various studies, summarized in a recent meta-analysis. As reams of evidence show, consumption of saturated fat contributes to atherosclerosis and heart disease, particularly compared to diets rich in polyunsaturated fats.

In several recent randomized control trials (RCTs), combinations of established, essential nutrients with antioxidant and heart-healthy properties have been evaluated. A combination of selenium and coenzyme Q10 (CoQ10) led to a 12 percent reduction in cardiovascular mortality risk in healthy elderly people.This effect was even more pronounced in subjects with low circulating selenium levels. Selenium, an essential mineral micronutrient, is shown to have several useful activities for cancer prevention and antioxidant support, particularly in its organically bound forms. It may be no surprise that a significant benefit on cardiovascular mortality was found for selenium supplementation in people with low blood levels.

As new science emerges on heart-healthy ingredients and products, we can develop smarter, better products. Over the long term, it will be good, hard science serving at the “heart" of our knowledge on cardiovascular health.

Hear Blake Ebersole preview the session by listening to SupplySide West Podcast 36: Nutrients for Heart Health and Beyond.

Learn more about heart health nutrient research from Blake Ebersole during the Nutrition for Heart Health workshop on Friday, Sept. 29 at 8:30 a.m. at SupplySide West in Las Vegas. The Workshop is underwritten by Nicolas Hall and CompaniesJapan Bio Sciences Lab and Natec.

Blake Ebersole has led a number of botanical quality initiatives and formed collaborations with dozens of universities and research centers. As president of NaturPro Scientific (, Ebersole established quality compliance and product development services for supplements and ingredients such as ID Verified™. Follow him on Twitter at @NaturalBlake. For a list of references, email [email protected].

About the Author(s)

Blake Ebersole

President, NaturPro Scientific

Blake Ebersole has led several botanical quality initiatives and formed collaborations with dozens of universities and research centers. As president of NaturPro Scientific, Ebersole established quality compliance and product development services for supplements and ingredients such as ID Verified™. Follow him on Twitter at @NaturalBlake.

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