Food & Beverage Perspectives
milk_vitamin D

Vitamin D May Protect Against Colorectal Cancer

<p>Although products such as milk are often fortified with vitamin D, almost 50 percent of Americans are still deficient in vitamin D. And to further support the need for vitamin D, a new study conducted by the Dana-Farber Cancer Institute found vitamin D can protect some people with colorectal cancer by perking up the immune system&#8217;s vigilance against tumor cells.</p>

Vitamin D, often referred to as the sunshine vitamin, has received a lot of attention in the past decade. It’s linked to mood, immune health, bone health and more. In October, we reported on a new study that found pregnant women with low vitamin D levels experience an increased amount of pain during labor.

Although products such as milk are often fortified with vitamin D, almost 50 percent of Americans are still deficient in vitamin D. To further support the need for vitamin D, a new study conducted by the Dana-Farber Cancer Institute found vitamin D can protect some people with colorectal cancer by perking up the immune system’s vigilance against tumor cells (Gut. Jan. 15, 2015). This is the first time a link between vitamin D and the immune response to cancer has been shown in a large human population.

“People with high levels of vitamin D in their bloodstream have a lower overall risk of developing colorectal cancer," said the study’s senior author, Shuji Ogino, M.D., Ph.D., of Dana-Farber, Harvard School of Public Health, and Brigham and Women’s Hospital. “Laboratory research suggests vitamin D boosts immune system function by activating T cells that recognize and attack cancer cells. In this study, we wanted to determine if these two phenomena are related: Does vitamin D’s role in the immune system account for the lower rates of colorectal cancer in people with high circulating levels of the vitamin?"

Ogino and his colleagues theorized if the two phenomena were connected, then people with high levels of vitamin D would be less likely to develop colorectal tumors that are permeated with large numbers of immune system cells. Colorectal tumors that do develop in these individuals would, by the same logic, be more resistant to the immune response.

Therefore, the research team drew on data from 170,000 participants in the Nurses’ Health Study and Health Professionals Follow-p Study, two long-term health-tracking research projects. Within this population, researchers compared carefully selected groups of 318 colorectal cancer patients and 624 individuals who were free of cancer. All 942 of them had blood samples drawn in the 1990s, before any developed cancer. The investigators tested these samples for 25(OH)D. They found patients with high amounts of 25(OH)D had a lower-than-average risk of developing colorectal tumors that were enriched with immune system cells.

“This is the first study to show evidence of the effect of vitamin D on anticancer immune function in actual patients, and vindicates basic laboratory discoveries that vitamin D can interact with the immune system to raise the body’s defenses against cancer," Ogino said. “In the future, we may be able to predict how increasing an individual’s vitamin D intake and immune function can reduce his or her risk of colorectal cancer."

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