BASEL, Switzerland—New study results show Lonza’s proprietary MemreePlus™ ingredient can help support memory and cognitive function, which is especially apparent in those who have developed cognition deficiencies. (Advances in Therapy. 2014 Nov; Online.)  

The two studies, funded by Lipogen, used soy lecithin-derived phosphatidylserine (PS) and phosphatidic acid (PA). Doses used included a combination of 100-mg PS and 80-mg PA three times per day.

The first study, a three-month, double-blind, placebo-controlled study with PS and PA in 72 functioning, non-depressive elderly with memory problems, demonstrated a statistically significant positive influence of PS and PA on memory, mood and cognition in pre-post comparison.

The second study, a two-month, randomized, double-blind, placebo-controlled study with PS and PA in 96 patients with Alzheimer’s disease, demonstrated a significant stabilizing effect of PS and PA on daily functioning, when comparing both groups. There also were some improvements in emotional state and self-reported general condition in the PS + PA group; no negative side effects were observed.

At the conclusion of the studies, the combination of PS and PA demonstrated a positive influence on memory, mood and cognition among elderly test subjects with memory problems. Therefore, the data encourage long-term studies with PS and PA in Alzheimer’s patients and other elderly with memory or cognition problems.

Additionally, the studies show PS is efficiently absorbed after oral consumption. Specifically, the studies showed serum PS peaked 90 minutes after ingestion, returning to baseline after 180 minutes. 

Earlier this year, another published study confirmed that supplementation with MemreePlus™ ingredient can support a normal stress response in chronically stressed male adults.