Lignans May Reduce Uterine Fibroids

December 11, 2006

2 Min Read
Lignans May Reduce Uterine Fibroids

LOCARNO, Switzerland—In a study published in the American Journal of Clinical Nutrition (84:587-93, 2006), a possible relationship was found between dietary lignans and risk of uterine fibroids. Researchers analyzed 170 uterine fibroid cases and 173 controls for isoflavonoids (i.e. genistein, daidzein, equol) and lignans (enterolactone and enterodiol). Researchers collected two overnight urine samples (48 hours apart); logistic regression was used to determine associations between excretion and the risk of uterine fibroids. Findings suggest a modest inverse association between lignan excretion and uterine fibroid risk. When considering two human lignans measured, this association was most notable for enterolactone. No association was found between isoflavone excretion and uterine fibroids, yet the researchers noted that soy intake was low in this study population.

“Although these new data on uterine fibroids are preliminary in nature, it may be sensible to consider that 7-hydroxymatairesinol a useful dietary supplement for women who are concerned about uterine fibroids,” said Robin Ward, vice president of marketing for Linnea, the supplier of HMRlignan™.

In addition, 7-hydroxymatairesinol was found to be the dominating lignan in wheat, triticale, barley, corn, amaranth, and millet and oat bran. Researchers at the Abo Akedemi University, Department of Biochemistry and Pharmacy, analyzed 24 plant lignans through HPLC-MS/MS in bran extracts of 16 cereal species, four nut species and oilseeds (sesame and linseeds). Of these 24 lignans, 18 were previously unidentified in these sources; 16 of the lignans were identified in analyzed samples. According to study authors, the proportion of new lignans of the total lignan content exceeds 50 percent—i.e., the new lignans are dominant in wheat, barley, corn, and quinoa bran and in amaranth. Further, in triticale bran, the proportion is nearly 50 percent, and in rye, oats, buckwheat, millet, and dhurra bran, the proportion is between 26 and 44 percent. In spelt wheat and all rice species, the proportion is between 3 and 16 percent. Ward added, “With its abundance in grains and other foods, it is clear that 7-hydroxymatairesinol is a significant source of dietary lignans as part of a healthy diet regimen. The new research validates HMRlignan as an exceptional choice for inclusion in dietary supplements and functional foods.”

Subscribe and receive the latest insights on the health and nutrition industry.
Join 37,000+ members. Yes, it's completely free.

You May Also Like