Coffee May Lower Prostate Cancer RiskCoffee May Lower Prostate Cancer Risk
December 8, 2009
HOUSTONResearchers found a strong inverse association between coffee consumption and the risk of lethal and advanced prostate cancers, according to data presented at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference.
Coffee has effects on insulin and glucose metabolism as well as sex hormone levels, all of which play a role in prostate cancer. It was plausible that there may be an association between coffee and prostate cancer, said Kathryn M. Wilson, Ph.D., a postdoctoral fellow at the Channing Laboratory, Harvard Medical School and the Harvard School of Public Health.
In a prospective investigation, Wilson and colleagues found men who drank the most coffee had a 60 percent lower risk of aggressive prostate cancer than men who did not drink any coffee. This is the first study of its kind to look at both overall risk of prostate cancer and risk of localized, advanced and lethal disease. Using the Health Professionals Follow-Up Study, the researchers documented the regular and decaffeinated coffee intake of nearly 50,000 men every four years from 1986 to 2006; 4,975 of these men developed prostate cancer over that time. They also examined the cross-sectional association between coffee consumption and levels of circulating hormones in blood samples collected from a subset of men in the cohort.
Caffeine is actually not the key factor in this association, according to Wilson. The researchers are unsure which components of the beverage are most important, as coffee contains many biologically active compounds like antioxidants and minerals.
Very few lifestyle factors have been consistently associated with prostate cancer risk, especially with risk of aggressive disease, so it would be very exciting if this association is confirmed in other studies, said Wilson. Our results do suggest there is no reason to stop drinking coffee out of any concern about prostate cancer.
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