Kampo Formulation May Offer Cholera Therapy
CHIBA, Japan--Daio-kanzo-to, a Kampo formulation (traditional herbal medications used in China and Japan), may be an effective adjuvant therapy for severe diarrhea of cholera, according to an in vitro study published by researchers from Chiba University in the March 5 issue of the Proceedings of the National Academies of Science (99, 5:3042-46, 2002) (www.pnas.org). Researchers found that Daio-kanzo-to inhibited cholera toxin activity in Chinese hamster ovary cells. Specifically, the Daio (Rhei rhizoma) appeared to be responsible for this effect, and among several components purified from Daio extract, rhubarb galloyl-tannin (a gallate compound) was the most effective. Researchers concluded that Kampo formulations or their gallate components might be effective when combined with oral rehydration therapy for diarrhea associated with cholera infection.