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Review of Creatine Adverse Events

Review of Creatine Adverse Events

BRUSSELS, Belgium--In the September Sports Medicine (30:155-170, 2000), a review contrasted scientific data and media reports garnered for creatine supplementation. Short-, medium- and long-term use was examined along with reported adverse events caused by creatine.

Short-term (five days), medium-term (nine weeks) and long-term (up to five years) users' kidney function was monitored by clearance methods and urine protein excretion rates; no adverse events were reported for renal function. Gastrointestinal disturbances and muscle cramps were reported occasionally in healthy individuals, but the effects were anecdotal according to researchers. However, it was noted in the review that idiosyncratic effects may occur when large amounts of an exogenous substance containing an amino group are consumed, which may lead to an increased load on the liver and kidneys. "Interestingly, more and more that placebo or non-creatine consumers cramp more, get injured more often, have more dehydration issues and [experience] a greater incidence of gastronomical problems," said Conrad Earnest, Ph.D., at the Dallas-based Copper Institute for Aerobics Research. For more information, e-mail the head researcher at

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