Colostrum May Reduce NSAID-Induced Stomach Damage

LONDON--Administering colostrum may reduce the adverse gastrointestinal effects of non-steroidal anti-inflammatory drugs(NSAIDs), according to a study of two trials published in the June Clinical Science (100, 6:627-33, 2001) (www.ncbi.nlm.nih.gov). In the first five-day trial, researchers treated seven healthy men using NSAIDs with 125 mL of spray-dried, defatted bovine colostrum or whey protein. The second trial examined the effect of 125mL/d of colostrum on 15 patients, also on NSAIDs, for 15 days. Patients in the control groups were found to have a three-fold increase in gut permeability after takingNSAIDs, compared to the colostrum-administered groups that experienced no significant increase. The study's authors, led by RayPlayford, M.D., from Hammersmith Hospital, concluded that colostrum may be a novel approach to preventingNSAID-induced gastrointestinal damage.