Animal Study: Tocotrienols Protect GI Tract

A new animal study sheds light on how vitamin E tocotrienols from annatto protect the gastrointestinal (GI) tract against injury.

HADLEY, Mass.A new animal study sheds light on how vitamin E tocotrienols from annatto protect the gastrointestinal (GI) tract against injury. The research, published in the Polish Journal of Pathology, found a non-antioxidant mechanism allowed the compound to shield the rats' gastric mucosa from stress-induced injury (Pol J Pathol. 2013 Apr;64(1):52-8.).

Researchers said stress is implicated as a risk factor in many health issues, including gastric lesion formation. This study was designed and carried out to study the gastro-protective effects of the most potent isoform of tocotrienol, delta-tocotrienol," the Universiti Teknologi MARA, Malaysia researchers said.

In the study, researchers induced GI distress in rats using water immersion and restraint. The subjects received 60mg/kg of annatto tocotrienol (as DeltaGold®, from American River Nutrition) or placebo daily for four weeks prior to stress introduction. Scientists found the rats' gastric lesion score was significantly lower in the supplemented group; the tocotrienol also reduced the lesion amount 2.2-fold.

This study is significant because tocotrienol may protect against gastric injury caused by widespread use of common painkillers, such as NSAIDs," said Barrie Tan, Ph.D., president of American River Nutrition.

Hide comments

Comments

  • Allowed HTML tags: <em> <strong> <blockquote> <br> <p>

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Publish