Peptan Benefits Bone HealthPeptan Benefits Bone Health
December 17, 2009
PARISDietary hydrolyzed collagen (as Peptan) increases osteoblast activity, which acts on bone remodeling and increases the external diameter of cortical areas of the femurs, according to a recent study in Bone journal (2009; DOI:10.1016/j.bone.2009.10.035). An in vivo study was carried out in 12-week-old female C3H/HeN mice, either ovariectomized (OVX) or sham-operated (SHAM) and fed for 12 weeks with a diet containing 10 or 25 g/kg of hydrolyzed collagen.
The bone mineral density (BMD) for OVX mice fed the diet including 25 g/kg of hydrolyzed collagen was significantly higher as compared to OVX mice. The blood C-terminal telopeptide of type I collagen (CTX) level significantly decreased when mice were fed with either of the diets containing hydrolyzed collagen. There was a significant increase in bone strength correlated to geometrical changes for the OVX mice fed the 25 g/kg hydrolyzed collagen diet. Hydrolyzed collagens in the tissue culture medium did not have any significant effects on cell growth as compared to controls. However, there was a significant and dose-dependent increase in alkaline phosphatase (ALP) activity, a well-known marker of osteogenesis, and a decrease in octeoclast activity in primary culture of bone cells cultured with hydrolyzed collagens as compared to the control.
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