It is estimated more than 120 million people worldwide are affected by depression, according to the World Health Organization (WHO), making it the leading cause of disability worldwide and a major contributor to the global disease burden. However, an article from Gerson Lehrman Group noted holistic treatment approaches may have a key role to play in addressing mild to moderate depression. Their definition of holistic medicine encompasses any methodology that helps address the basic underlying cause of a health condition, such as diet and exercise.
Natural medicines in particular were cited for their potential in this area. St. John’s wort (Hypericum perforatum), has been used in herbal tinctures since Roman times, and is used extensively today in Europe and the United States in cases of mild to moderate depression. Studies have found its efficacy in mild- to moderate-depression is comparable to that of imipramine (a common anti-depressant), generally with fewer side effects and better tolerance; studies have been less promising in severe depression. Researchers are continuing to examine the mechanism of action of St. John’s wort, as it may affect the uptake of certain neurotransmitters. They are also looking at its ability to affect uptake and synthesis of certain drugs, making it important for any person considering using St. John’s wort for depression to consult with a health care provider and review current medication usage.
Another potential botanical remedy in the area of mood disorders is kava (Piper methysticum). The root has been traditionally used in the South Pacific for its anxiolytic effects, and more current studies have demonstrated efficacy over placebos when used by patients suffering from anxiety. However, it should also be used with caution as there have been some concerns about hepatotoxicity or drug interaction.
