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PUFAs Fight Neuroinflammation


TORONTO—Omega-3s appear to regulate neuroinflammation, possibly fighting progression of neurological diseases such as Alzheimer’s, according to a new study (Neurochem Int. 2010 Mar;56(4):585-9. DOI:10.1016/j.neuint.2009.12.022). Researchers from the University of Toronto looked at the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) on brain cortex fatty acid composition and the expression of certain inflammatory mediators linked to the arachidonic acid cascade in the transgenic fat-1 mouse, engineered to have abundant levels of omega-3s. The team found omega-3 levels were up to 220 percent higher and omega-6 levels 77 percent lower in fat-1 phospholipid fractions of the cortex in the fat-1 mice; COX-2 protein levels were also 25 percent lower in fat-1 mice.

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