WUXI, China--A dyslipidemic diet adversely affects bone metabolism and the bone antioxidant system, according to research conducted by scientists at the School of Food Science and Technology at Jiangnan University and published online ahead of print in Nutrition journal. Compared to a normal diet, feeding mice a high-fat diet inhibited bone formation and enhanced bone resorption, in addition to impairing the bone antioxidant system. The dyslipidemic diet also led to low levels of insulin-like growth factor -1 in plasma and in bone, as well as high levels of tumor necrosis factor-alpha (TNF-a) in plasma, but not in bone. Mice given the high-fat diet plus the antioxidant lipoic acid partially or completely prevented such adverse bone health effects. The researcehrs concluded dyslipidemia negatively affects the bone antioxidant system, and oxidative stress might mediatedyslipidemia-induced bone loss.
