LEIDEN, Netherlands—Nutrigenomics are proving their impact on health and overall well-being. An intervention with selected dietary products, including resveratrol, green tea extract, alpha-tocopherol, vitamin C, omega-3 polyunsaturated fatty acids and tomato extract affected inflammatory processes, oxidative stress and metabolism in humans, as shown by large-scale profiling of genes, proteins and metabolites in plasma, urine and adipose tissue (Am J Clin Nutr Feb. 24, 2010). Dietary products selected for their evidence-based anti-inflammatory properties were combined and given as supplements to 36 healthy overweight men with mildly elevated plasma C-reactive protein concentrations in a double blind, placebo-controlled, crossover study with treatment periods of five weeks.
Plasma adiponectin concentrations increased by 7 percent, whereas C-reactive protein (principal inflammation marker) was unchanged. However, a multitude of subtle changes were detected by an integrated analysis of the "omics" data, which indicated modulated inflammation of adipose tissue, improved endothelial function, affected oxidative stress and increased liver fatty acid oxidation.
