ATHENS, Greece—Alpha-tocopherol supplementation in basketball players may protect the enzyme PON1/Aryl activities from free radical production, according to a recent study (Eu J Clin Nutr. 2009;63:215-221). Blood was obtained from 10 basketball players pre- (group A), post-exercise (group B) and after one month on 200 mg/24 hours alpha-tocopherol supplementation pre- (group C) and post-exercise (group D). Lactate, pyruvate, muscle enzyme activities and catecholamines were increased (P<0.001) in all groups post-training. Alpha-tocopherol levels remained unaltered pre- versus post-exercise. Total antioxidant status was decreased in all the groups post training. Paraoxonase 1/arylesterase (PON 1/Aryl) activities were significantly decreased post-exercise (group B) as compared to those pre-exercise (group A). In contrast, the studied enzyme activities remained practically unaltered after alpha-tocopherol supplementation pre- versus post-training. Both enzyme activities positively correlated to total antioxidant status.