AMERICAN FORK, Utah—New research suggests compounds in Mango.xan mangosteen juice supplement bind to certain adrenergic receptor cells linked to energy and fat metabolism. Pure Fruit Technologies will present the research results at the upcoming American Chemical Society's 62nd Annual Northwest Regional Meeting, scheduled for held June 17 to 20, in Boise, Idaho.
Wayne Geilman, Ph.D., senior research scientists at Pure Fruit, and his team, including leading noni researcher Afa K. Palu from Tahitian Noni International, investigated the in vitro effects of Mango.xan on adrenergic receptors, finding a concentration-dependent binding to and stimulation of beta-1 and -3 receptors; the effect on beta-3 was the most pronounced.
The researchers explained beta adrenergic receptors are linked to G proteins, which are involved in secondary messenger cascades that transduce signals into a cellular change. And G proteins are linked to adenylyl cyclase, the main enzyme involved in the production of cyclic adenosine monophosphate (cAMP), which contributes to the activation of protein kinase A (PKA), thereby increasing metabolism and promoting lipid breakdown.
"The results show that Mango-xan has the potential to be used as a weight management tool in conjunction with a proper diet and exercise," Geilman said. "Future research is needed to determine dosage and efficacy of Mango.xan using human clinical trials."
For more information on the study, visit NorthwestChemistry.org.