In an intervention study conducted at Hospital Broussais, 13 outpatients (aged 39 to 67) with diabetes suffering from microcirculatory disorders were treated with 2 mg/d of Daflon, a micronized flavonoid fraction (90 percent diosmin and 10 percent flavonoid), for one month. Daflon supplementation increased capillary permeability in all cases, while 12 out of 13 cases showed normalization of albumin retention, and it normalized abnormal pathological lymphatic fluctuations in six patients. In a parallel group of 15 patients not treated with Daflon, the initially abnormal test remained abnormal five to 48 months later in all patients.
Diosmin, a member of the flavonoid family, is synthesized from Hesperidin and has been used for more than 30 years as a phlebotonic and vascular-protecting agent. The study was published in International Angiology (8:27-29, 2006) (www.nature.com/ijo/index.html).