MAASTRICHT, Netherlands—A recent study at Maastricht University found the acute effect on satiety exerted by a high-protein lunch is not due to increased concentrations of satiety-related hormones (J Nutr. 2008;138:698-702). In a single blind, randomized, crossover design subjects’ energy expenditure and substrate oxidation were measured. After a standard subject-specific breakfast, subjects were randomly assigned a normal protein lunch (10 percent energy protein, 60 percent energy carbohydrates, 30 percent fat) or a high-protein lunch (25 percent energy protein, 45 percent energy carbohydrate, 30 percent fat). Post-lunch energy expenditure had a tendency to be greater after the high-protein lunch than after the normal lunch (p=.07); however, the respiratory quotient didn’t differ between the two treatments. Satiety measurements were significantly higher at 30 and 120 minutes after the high-protein lunch than after the normal lunch. The meals’ effects on satiety and diet-induced thermogenesis didn’t occur simultaneously with changes in plasma ghrelin, glucagon-like peptide 1 and peptide tyrosine-tyrosine concentrations. Researchers said other factors that may explain high protein’s effect on satiety could be metabolites or amino acids.
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