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Strengthening the Immune System (The Body's Internal Battle: Immune Health)

Alissa Marrapodi
08/04/2008
Continued from page 6
Probiotics containing beneficial bacteria are gaining momentum with growing research pointing to their positive impact on immune and digestive health. Mice were given 50 μl/d of either L. acidophilus L10 or L. paracasei L26 (108 CFU) during a 14-day feeding trial in New South Wales, Australia.19 The proliferative responses of splenocytes to concanavalin A (sparks lymphocyte mitosis, or cell division) and LPS were significantly higher in mice fed L. acidophilus. Concanavalin A-induced splenocyte proliferative responses increased significantly in mice fed L. paracasei. Interleukin 10 and interferon γ production from the splenocytes stimulated with concanavalin A were enhanced in mice fed L. acidophilus or L. paracasei. The phagocytic activity of the peritoneal macrophages was significantly higher in mice fed either L. acidophilus or L. paracasei compared with control mice. In mice fed L. acidophilus or L. paracasei, the bacterial translocation of Lactobacillus spp. and total anaerobes to Peyer’s patches and mesenteric lymph nodes was modulated compared with that in the control mice. Furthermore, there was no indication of disruption of intestinal mucosal integrity and thus no bacterial translocation to spleen, liver or blood in mice fed either L. acidophilus or L. paracasei.

Similarly, a randomized, controlled, double blind nutritional intervention study with parallel groups with a sample size of 104 women, found intake of milk fermented with L. casei during the lactation period modestly contributed to the modulation of the mother’s immunological response after delivery and decreased the incidence of gastrointestinal episodes in the breast-fed child.20 After consuming the L. casei milk, reseachers observed a non-significant increase in T and B lymphocytes and a significant increase in NK cells. A decrease in the pro-inflammatory cytokine TNF-alpha in maternal milk and fewer gastrointestinal disturbances were also observed in the breast-fed child of the mothers who consumed L. casei. Additionally, the probiotic strain L. casei CRL 431 demonstrated great activity on the immune cells and the enriched population in intestinal epithelial cells, activating mainly cells of the innate immune system in an Argentine study.21

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