References1. Harris Interactive, on behalf of Schering-Plough and GlaxoSmithKline. 2. Men's Health Network, http://www.menshealthnetwork.org 3. Shoskes DA et al. " Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial." Urology. 1999;54(6):960-3. 4. Shahed AR and Shoskes DA. "Correlation of beta-endorphin and prostaglandin E2 levels in prostatic fluid of patients with chronic prostatitis with diagnosis and treatment response." J Urol. 2001;166(5):1738-41. 5. Lou JG et al. "Increased oxidative stress and damage in patients with chronic bacterial prostatitis." Biomed Environ Sci. 2006;19(6):481-6. 6. Comhaire F and Mahmoud A. "Preventing diseases of the prostate in the elderly using hormones and nutriceuticals." Aging Male. 2004;7, 2:155-69. 7. Wilt TJ et al. “Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review.” JAMA. 1998; 280, 18:1604–1609. http://jama.ama-assn.org 8. Ishani A et al. “Serenoa repens for benign prostatic hyperplasia.” Cochrane Data Syst Rev. 3:CD001423, 2002. 9. Bent S et al. "Saw palmetto for benign prostatic hyperplasia." N Engl J Med. 2006 Feb 9;354(6):557-66. 10. Choo MS et al. "Functional evaluation of Tadenan on micturition and experimental prostate growth induced with exogenous dihydrotestosterone." Urology. 2000;55, 2:292-8. http://www.sciencedirect.com/science/journal/00904295 11. Friederich M et al. "Prosta Fink Forte capsules in the treatment of benign prostatic hyperplasia. Multicentric surveillance study in 2245 patients." Forsch Komplementarmed Klass Naturheilkd. 2000;7:200-4. [in German]. 12. Rohrmann S et al. "Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in U.S. men." Am J Clin Nutr. 2007;85(2):523-9. 13. Kristal AR et al. "Dietary Patterns, Supplement Use, and the Risk of Symptomatic Benign Prostatic Hyperplasia: Results from the Prostate Cancer Prevention Trial. Am J Epidemiol. 2008 Feb 7, Epub ahead of print. 14. Crispo A et al. "Alcohol and the risk of prostate cancer and benign prostatic hyperplasia." Urology. 2004 Oct;64(4):717-22. 15. Kucuk O et al. “Effects of lycopene supplementation in patients with localized prostate cancer.” Exp Biol Med. (Maywood). 2002; 227, 10:881-5. www.ebmonline.org 16. Peters U et al. "Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial." Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):962-8. 17. Takada Y et al. "Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappaB and NF-kappaB-regulated gene expression." J Immunol. 2006;176, 5:3127-40. 18. Malik A et al. “Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.” Proc Natl Acad Sci. 2005;102, 41:14813-8. www.pnas.org 19a. Hsing AW et al. "Allium vegetables and risk of prostate cancer: a population-based study." J Natl Cancer Inst. 2002;94, 21:1648-51. http://jncicancerspectrum.oupjournals.org/jnci 19b. Lee MM et al. “Soy and isoflavone consumption in relation to prostate cancer risk in China.” Cancer Epidemiol Biomarkers Prev. 2003;12, 7:665-8. http://cebp.aacrjournals.org 20. Durak I et al. “Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer.” Nutr Res. 2003;23, 2:199-204. www.elsevier.com/locate/issn/02715317 21. Bylund A et al. “Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice.” Prostate. 2000;42, 4:304-14. www.wileyeurope.com/WileyCDA/WileyTitle/productCd-PROS.html 22. Bergan RC et al. "Dietary genistein inhibits metastasis of human prostate cancer in mice." Cancer Res. 2008;68(6):2024-32. 23. Hedelin M et al. "Dietary phytoestrogen, serum enterolactone and risk of prostate cancer: the Cancer Prostate Sweden Study." Cancer Cause Control. 2006;17:169-80. 24. Bylund A et al. "Anticancer effects of a plant lignan 7-hydroxymatairesinal on a prostate cancer model in vivo." Exp Biol Med (Maywood). 2005;230, 3:217-23. 25. Fitzgerald JM et al. “Intake of selenium in the prevention of prostate cancer: a systematic review and meta-analysis.” Cancer Causes Control. 2005;16, 9:1125-31. www.springerlink.com/link.asp?id=100150 26. Waters DJ et al. “Effects of dietary selenium supplementation on DNA damage and apoptosis in canine prostate.” J Natl Cancer Inst. 2003;95, 3:237-41. http://jncicancerspectrum.oupjournals.org/jnci 27. Gazzaruso C et al. " Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients." Circulation. 2004;110(1):22-6. 28. Thomspon IM et al. " Erectile dysfunction and subsequent cardiovascular disease." JAMA. 2005;294(23):2996-3002. 29. Benelli A et al. "Nitric oxide is involved in male sexual behavior of rats." Eur J Pharmacol.1995;294(2-3):505-10. 30. Kim NN et al. "Role of arginase in the male and female sexual arousal response." J Nutr. 2004; 134(10 Suppl):2873S-2879S. www.nutrition.org 31. Lebret T et al. "Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction." Eur Urol. 2002;41, 6:608-13. www.sciencedirect.com 32. McKay D. "Nutrients and botanicals for erectile dysfunction: examining the evidence." Altern Med Rev. 2004;9, 1:4-16. www.thorne.com/altmedrev/.fulltext/9/1/4.pdf 33. Hong B et al. "A Double-Blind Crossover Study Evaluating the Efficacy of Korean Red Ginseng in Patients With Erectile Dysfunction: A Preliminary Report." J Urology. 2002;168, 5:2070-3. www.jurology.com 34. Stanislavov R et al. " Improvement of erectile function with Prelox: a randomized, double-blind, placebo-controlled, crossover trial." Int J Impot Res. 2008;20(2):173-80. 35. Trebaticky B et al. "Lipid metabolism and erectile function improvement by pycnogenol®, extract from the bark of pinus pinaster in patients suffering from erectile dysfunction-a pilot study." Nutr Res. 2003;23, 9:1189-98. http://www.sciencedirect.com/science/journal/02715317 36. Forest CP et al. " Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study." Int J Impot Res. 2007;19(6):564-7. 37. Turk G et al. " Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats." Clin Nutr. 2008;27(2):289-296. 38. Cavallini G et al. "Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging." Urology. 2004;63, 4:641-6. www.sciencedirect.com 39. Agarwal A, Said TM. "Carnitines and male infertility." Reprod Biomed Online. 2004;8, 4:376-84. http://dandini.ingentaselect.com 40. Vicari E et al. "Antioxidant therapeutic efficiency after the use of carnitine in infertile patients with bacterial or non bacterial prostato-vesiculo-epididymitis." Arch Ital Urol Androl. 2001;73, 1:15-25. 41. A. Lenzi et al. "Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial." Fertil Steril. 79, 2:292-300, 2003. www.sciencedirect.com 42. Soufir JC et al. "Levels of seminal free L(-) carnitine in fertile and infertile men." Int J Androl. 1984;7, 3:188-97. 43. Cavallini G et al. "Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging." Urology. 2004;63, 4:641-6. www.sciencedirect.com 44. Gonzales GF et al. "Red maca (Lepidium meyenii) reduced prostate size in rats." Reprod Biol Endocrinol. 2005;3, 1:5. 45. Gonzales GF et al. "Lepidium meyenii (Maca) improved semen parameters in adult men." Asian J Androl. 2001;3, 4:301-3. www.asiaandro.com/1008-682X/3/301.htm 46. Gonzales GF et al. "Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m)." J Endocrinol. 2004;180, 1:87-95. http://joe.endocrinology.journals.org 47. Gonzales GF et al. "Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats." Asian J Androl. 2001;3, 3:231-3,. www.asiaandro.com/1008-682X/3/231.htm 48. Gonzales GF et al. "Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats." Asian J Androl. 2003;5, 4:349-52. www.asiaandro.com/1008-682X/5/349.htm 49. Merkus HM et al. " Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial." Fertil Steril. 2002;77(3):491-8. 50. Ervin RB et al. " Use of dietary supplements in the United States, 1988-94." Vital Health Stat 11. 1999;(244):i-iii, 1-14. 51. Rao AV. "Lycopene, tomatoes and the prevention of coronary heart disease." Exp Biol Med (Maywood). 2002;227, 10:908-13. 52. Noguchi T et al. "Nutritional prevention on hypertension, cerebral hemodynamics and thrombosis in stroke-prone spontaneously hypertensive rats." Cell Mol Neurobiol. 2004;24, 5:599-638. 53. Cui J et al. "Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts." Mol Cell Biochem. 2003;254, 1-2:227-34. www.wkap.nl 54. . Zhan S and Ho S. “Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile.” Am J Clin Nutr. 2005;81, 2:397-408. www.ajcn.org 55. Ackermann RT et al. "Garlic shows promise for improving some cardiovascular risk factors." Arch Intern Med. 2001;161, 6:813-24. http://archinte.ama-assn.org 56. Singer GM et al. " The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial." Diabetes Technol Ther. 2006 Dec;8(6):636-43. 57. Wang ZQ et al. "Chromium Picolinate Enhances Skeletal Muscle Cellular Insulin Signaling In Vivo in Obese, Insulin-Resistant JCR:LA-cp Rats." J Nutr. 2006;136:415-420. www.nutrition.org 58. Anderson RA et al. "Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes." Diabetes. 1997;46, 11:1786-91. http://diabetes.diabetesjournals.org 59. Komorowski JR et al. "Effect of chromium picolinate and biotin combination as an adjunctive nutritional therapy in poorly-controlled patients with diabetes mellitus." Abstract 749, PS 61 Nutrition and Diet II.. Presented at European Association for the Study of Diabetes annual meeting, 2005. 60. Schnyder G et al. "Effect of homocysteine-lowering therapy with folic acid, vitamin B12 and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial." JAMA. 2002;288, 8:973-9. http://jama.ama-assn.org 61. Larsson SC et al. " Folate, Vitamin B6, Vitamin B12, and Methionine Intakes and Risk of Stroke Subtypes in Male Smokers." Am J Epidemiol. 2008 Feb 12; [Epub ahead of print]. 62. Cannelly PJ et al. "A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease." Int J Geriatr Psychiatry. 2008 Feb;23(2):155-60. 63. Oarada M et al. " Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice." Nutrition. 2008 Jan;24(1):67-75. 64. Yokoyama M et al. " Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis." Lancet. 2007 Mar 31;369(9567):1090-8. 65. Kabir M et al. "Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study." Am J Clin Nutr. 2007 Dec;86(6):1670-9. 66. Afkhami-Ardekani M and Shojaoddiny-Ardekani A. "Effect of vitamin C on blood glucose, serum lipids & serum insulin in type 2 diabetes patients." Indian J Med Res. 2007;126(5):471-4. 67. Lee SK et al. " Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production." J Cell Physiol. 2008 Feb 22; [Epub ahead of print]. 68. Myint PK et al. " Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study." Am J Clin Nutr. 2008 Jan;87(1):64-9. 69. Rosa EF et al. " Oxidative stress induced by intense and exhaustive exercise impairs murine cognitive function." J Neurophysiol. 2007 Sep;98(3):1820-6. 70. Lenton KJ et al. "Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency." Am J Clin Nutr. 77, 1:189-95, 2003. www.ajcn.org 71. Kontush K and Schekatolina S. "Vitamin E in neurodegenerative disorders: Alzheimer's disease." Ann N Y Acad Sci. 2004;1031:249-62. 72. Shirpoor A et al. " Cardioprotective effect of vitamin E: rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat." J Diabetes Complications. 2008 Apr 2; [Epub ahead of print] 73. Milman U et al. " Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial." Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):341-7. 74. Appenroth D et al. " LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol." Toxicol Lett. 2001 Jul 6;122(3):255-65. 75. Mittal M, Flora SJ. " Vitamin E supplementation protects oxidative stress during arsenic and fluoride antagonism in male mice." Drug Chem Toxicol. 2007;30(3):263-81. 76. Sengupta A et al. “Tea can protect against aberrant crypt foci formation during azoxymethane induced rat colon carcinogenesis.” J Exp Clin Cancer Res. 22(2):185-91, 2003. 77. Bettuzzi S et al. “The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression.” Carcinogenesis. 25, 11:2217-24, 2004. http://carcin.oupjournals.org 78. Vinson JA, Teufel K, Wu N. "Green and black teas inhibit atherosclerosis by lipid, antioxidant and fibrinolytic mechanisms." J Agric Food Chem. 2004;52, 11:3661-5. http://pubs.acs.org/journals/jafcau 79. Chyu KY et al. "Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice." Circulation. 2004;109, 20:2448-53. http://circ.ahajournals.org 80. Lee YS et al. " Synergistic effect between catechin and ciprofloxacin on chronic bacterial prostatitis rat model." Int J Urol. 2005 Apr;12(4):383-9. 81. Han MK. "Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic beta-cell damage." Exp Mol Med. 2003;35, 2:136-9. 82. Yokozowa T et al. " Green tea polyphenols and dietary fibre protect against kidney damage in rats with diabetic nephropathy." J Pharm Pharmacol. 2005 Jun;57(6):773-80. 83. Choi YT et al. "The green tea polyphenol, (-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons." Life Sci. 2001;70, 5:603-14. www.sciencedirect.com 84. Zibadi S et al. " Impact of Pycnogenol on cardiac extracellular matrix remodeling induced by L-NAME administration to old mice." Cardiovasc Toxicol. 2007;7(1):10-8. 85. Huang WW et al. " Pycnogenol induces differentiation and apoptosis in human promyeloid leukemia HL-60 cells." Leuk Res. 2005 Jun;29(6):685-92. 86. Liu X et al. "Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II." Life Sci. 2004;75, 21:2505-13. www.elsevier.com 87. Peng QL et al. " Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis." Brain Res Mol Brain Res. 2002 Jul 15;104(1):55-65. 88. Roseff SJ. " Improvement in sperm quality and function with French maritime pine tree bark extract." J Reprod Med. 2002 Oct;47(10):821-4. 89. Lei F et al. " Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice." Int J Obes (Lond). 2007 Jun;31(6):1023-9. 90. ibid. 91. Malik A et al. “Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.” Proc Natl Acad Sci. 2005;102, 41:14813-8. www.pnas.org Pages: Previous 1 2 3 4 5
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