Circulatory Function and Vascular Integrity

Supporting vascular integrity to enhance circulatory function

References

1. Michalsen A, Dobos GJ. “[Effects of nutritional factors on haemostasis.]” Hamostaseologie. 2005 Feb;25(1):13-7.

2. Kay CD, Kris-Etherton PM, West SG. “Effects of antioxidant-rich foods on vascular reactivity: review of the clinical evidence.” Curr Atheroscler Rep. 2006 Nov;8(6):510-22.

3. Fung TT et al. “Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction.” Am J Clin Nutr. 2005 Jul;82(1):163-73.

4. Fuentes F et al. “Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men.” Br J Nutr. 2008 Feb 14;:1-7 [Epub ahead of print].

5. Cortés B et al. “Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function.” J Am Coll Cardiol. 2006 Oct 17;48(8):1666-71. Epub 2006 Sep 26.

6. Schwalfenberg G. “Omega-3 fatty acids: their beneficial role in cardiovascular health.” Can Fam Physician. 2006 Jun;52:734-40.

7. Demaison L, Moreau D. “Dietary n-3 polyunsaturated fatty acids and coronary heart disease-related mortality: a possible mechanism of action.” Cell Mol Life Sci. 2002 Mar;59(3):463-77.

8. Armah CK et al. “Fish oil fatty acids improve postprandial vascular reactivity in healthy men.” Clin Sci (Lond). 2007 Dec 3 [Epub ahead of print].

9. Shah AP et al. “Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers.” J Cardiovasc Pharmacol Ther. 2007 Sep;12(3):213-9.

10. Wannamethee SG et al. “Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis.” Am J Clin Nutr. 2006 Mar;83(3):567-74.

11. Sabharwal AK, May JM. “alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells.” Mol Cell Biochem. 2008 Feb;309(1-2):125-32. Epub 2007 Nov 16.

12. Ulrich-Merzenich G et al. “Vitamin C promotes human endothelial cell growth via the ERK-signaling pathway.” Eur J Nutr. 2007 Mar;46(2):87-94.

13. Pleiner J et al. “Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion.” Atherosclerosis. 2008 Mar;197(1):383-91. Epub 2007 Jul 23.

14. Obad A et al. “Antioxidant pretreatment and reduced arterial endothelial dysfunction after diving.” Aviat Space Environ Med. 2007 Dec;78(12):1114-20.

15. Antoniades C et al. “Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers.” Thromb Haemost. 2003 Jun;89(6):990-5.

16. Vignini A et al. “A study on the action of vitamin E supplementation on plasminogen activator inhibitor type 1 and platelet nitric oxide production in type 2 diabetic patients.” Nutr Metab Cardiovasc Dis. 2008 Jan;18(1):15-22. Epub 2007 Oct 18.

17. Theriault A, Chaoa JT, Gaporb A. “Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes.” Atherosclerosis. 2002; 160(1):21-30.

18. Geleijnse JM et al. “Dietary intake of menquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study.” J Nutr. 2004;134:3100-05.

19. Spronk HMH et al. “Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats.” J Vasc Res. 2003;40:531-7.

20. Schurgers LJ et al. “Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats.” Blood. 2007;109:2823-31.

21. Cranenburg ECM, Schurgers LJ, Vermeer C. “Vitamin K: The coagulation vitamin that became omnipotent.” Thromb Haemost. 2007;98(1):120-5.

22. Cannon CP. “High-density lipoprotein cholesterol and residual cardiometabolic risk in metabolic syndrome.” Clin Cornerstone. 2007;8 Suppl 6:S14-23.

23. Thoenes M et al. “The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.” Int J Clin Pract. 2007 Nov;61(11):1942-8.

24. Taylor AJ, Lee HJ, Sullenberger LE. “The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3.” Curr Med Res Opin. 2006 Nov;22(11):2243-50.

25. Shirodaria C et al. “Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.” Circulation. 2007 May 1;115(17):2262-70. Epub 2007 Apr 9.

26. McCarty MF. “High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress.” Med Hypotheses. 2007;69(1):12-9. Epub 2007 Feb 12.

27. Tao X et al. “Treatment of Hyperhomocysteinemia and Endothelial Dysfunction in Renal Transplant Recipients With B Vitamins in the Chinese Population.” J Urol. 2008 Jan 16 [Epub ahead of print].

28. Macko RF et al. “Effects of vitamin therapy on plasma total homocysteine, endothelial injury markers, and fibrinolysis in stroke patients.” J Stroke Cerebrovasc Dis. 2002 Jan-Feb;11(1):1-8.

29. Littarru GP, Tiano L. “Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.” Mol Biotechnol. 2007 Sep;37(1):31-7.

30. Tiano L et al. “Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study.” Eur Heart J. 2007 Sep;28(18):2249-55. Epub 2007 Jul 19.

31. Belardinelli R et al. “Coenzyme Q10 and exercise training in chronic heart failure.” Eur Heart J. 2006 Nov;27(22):2675-81. Epub 2006 Aug 1.

32. Gornik HL, Creager MA. “Arginine and Endothelial and Vascular Health.” J Nutr. 2004;134:2880S-2887S.

33. Lin PH et al. “Rheolytic pharmacomechanical thrombectomy in experimental chronic deep vein thrombosis: effect of L-arginine on thrombogenicity and endothelial vasomotor function.” World J Surg. 2007 Apr;31(4):664-75.

34. Martina V et al. “Long Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial Activation and Systolic Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus.” Diabetes Care. 2008 Feb 11 [Epub ahead of print].

35. Corder R et al. “Oenology: red wine procyanidins and vascular health.” Nature. 2006 Nov 30;444(7119):566.

36. de Lange DW et al. “Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox.” Alcohol Clin Exp Res. 2007 Aug;31(8):1308-14. Epub 2007 Jun 9.

37. Olas B et al. “Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro.” Platelets. 2008 Feb;19(1):70-7.

38. Fitzpatrick DF et al. “Vasodilating procyanidins derived from grape seeds.” Ann N Y Acad Sci. 2002 May;957:78-89.

39. Edirisinghe I, Burton-Freeman B, Kappagoda CT. “Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.” Clin Sci. 2008;114:331-7.

40. Kappagoda CT et al. Experimental Biology Conference, April 30, 2007.

41. Morazzoni P et al. “Leucoselect™ Phytosome® in the management of chronic cardiovascular diseases.” Presented at Food & Nutrition for Better Health, Santa Maria Imbaro-Lanciano, Italy. June 14-15, 2001.

42. Vigna GB et al. “Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers.” Metabolism. 2003;52(10):1250-57.

43. Leblais V et al. “Relaxation induced by red wine polyphenolic compounds in rat pulmonary arteries: lack of inhibition by NO-synthase inhibitor.” Fundam Clin Pharmacol. 2008 Feb;22(1):25-35.

44. Wu CC et al. “Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins.” Planta Med. 2007 May;73(5):439-43.

45. Rush JW et al. “Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats.” Exp Biol Med (Maywood). 2007 Jun;232(6):814-22.

46. Hodgson JM. “Effects of tea and tea flavonoids on endothelial function and blood pressure: a brief review.” Clin Exp Pharmacol Physiol. 2006 Sep;33(9):838-41.

47. Jochmann N et al. “The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea.” Br J Nutr. 2007 Oct 5;:1-6 [Epub ahead of print].

48. Ardalan MR et al. “Black tea improves endothelial function in renal transplant recipients.” Transplant Proc. 2007 May;39(4):1139-42.

49. Kim JA et al. “Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn.” J Biol Chem. 2007 May 4;282(18):13736-45. Epub 2007 Mar 15.

50. Kang WS et al. “Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate.” Thromb Res. 1999 Nov 1;96(3):229-37.

51. Widlansky ME et al. “Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease.” J Am Coll Nutr. 2007 Apr;26(2):95-102.

52. Tedeschi E et al. “Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1-alpha activation.” Mol Pharmacol. 2004;65:111-20.

53. Townsend PA et al. “Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.” FASEB J. ePub Aug. 19, 2004. DOI:10.1096/fj.04-1716fje.

54. Vlachopoulos C, Alexopoulos N, Stefanadis C. “Effect of dark chocolate on arterial function in healthy individuals: cocoa instead of ambrosia?” Curr Hypertens Rep. 2006 Jun;8(3):205-11.

55. Pearson DA et al. “Flavanols and platelet reactivity.” Clin Dev Immunol. 2005 Mar;12(1):1-9.

56. Heptinstall S et al. “Cocoa flavanols and platelet and leukocyte function: recent in vitro and ex vivo studies in healthy adults.” J Cardiovasc Pharmacol. 2006;47 Suppl 2:S197-205.

57. Wang-Polagruto JF et al. “Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women.” J Cardiovasc Pharmacol. 2006;47 Suppl 2:S177-86.

58. Heiss C et al. “Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week.” J Cardiovasc Pharmacol. 2007 Feb;49(2):74-80.

59. Flammer AJ et al. “Dark chocolate improves coronary vasomotion and reduces platelet reactivity.” Circulation. 2007 Nov 20;116(21):2376-82. Epub 2007 Nov 5.

60. Perona JS, Cabello-Moruno R, Ruiz-Gutierrez V. “The role of virgin olive oil components in the modulation of endothelial function.” J Nutr Biochem. 2006 Jul;17(7):429-45. Epub 2005 Dec 12.

61. Rodriguez-Rodriguez R et al. “Pomace olive oil improves endothelial function in spontaneously hypertensive rats by increasing endothelial nitric oxide synthase expression.” Am J Hypertens. 2007 Jul;20(7):728-34.

62. Dell'agli M et al. “Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase.” Br J Nutr. 2007 Oct 11;:1-7 [Epub ahead of print].

63. Katsenis K. “Micronized purified flavonoid fraction (MPFF): a review of its pharmacological effects, therapeutic efficacy and benefits in the management of chronic venous insufficiency.” Curr Vasc Pharmacol. 2005 Jan;3(1):1-9.

64. Paysant J et al. “Different flavonoids present in the micronized purified flavonoid fraction (Daflon(R) 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation.” Int Angiol. 2008 Mar;27(1):81-5.

65. Lyseng-Williamson KA, Perry CM. “Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids.” Drugs. 2003;63(1):71-100.

66. Cesarone MR et al. “Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study.” Clin Appl Thromb Hemost. 2006 Apr;12(2):205-12.

67. Cesarone MR et al. “Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study.” Angiology. 2006 Oct-Nov;57(5):569-76.

68. Cesarone MR et al. “Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled study.” Angiology. 2006 Aug-Sep;57(4):431-6.

69. Bell DR, Gochenaur K. “Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts.” J Appl Physiol. 2006;100:1164-70.

70. O'Kennedy N et al. “Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans.” Am J Clin Nutr. 2006 Sep;84(3):561-9.

71. Dutta-Roy AK, Crosbie L, Gordon MJ. “Effects of tomato extract on human platelet aggregation in vitro.” Platelets. 2001 Jun;12(4):218-27.

72. Balestrieri ML et al. “Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress.” Free Radic Biol Med. 2004 Apr 15;36(8):1058-67.

73. Engelhard YN, Gazer B, Paran E. “Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study.” Am Heart J. 2006 Jan;151(1):100.

74. Sun X, Ku DD. “Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats.” Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2431-8. Epub 2006 May 26.

75. Ashraf MZ, Hussain ME, Fahim M. “Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide.” J Ethnopharmacol. 2004 Jan;90(1):5-9.

76. Rassoul F et al. “The influence of garlic (Allium sativum) extract on interleukin 1alpha-induced expression of endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1.” Phytomedicine. 2006 Mar;13(4):230-5. Epub 2005 Sep 15.

77. Weiss N et al. “Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro- and microcirculation.” J Nutr. 2006;136:750S-54S.

78. Williams MJA et al. “Aged garlic extract improves endothelial function in men with coronary artery disease.” Phytother Res. 2005;19:314-9.

79. Rahman K, Billington D. “Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans.” J Nutr. 2000;130:2662-2665.

80. Steiner M, Li W. “Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions.” J Nutr. 2001;131:980S-984S.

81. Birks J, Grimley Evans J. “Ginkgo biloba for cognitive impairment and dementia.” Cochrane Database Syst Rev. 2007 Apr 18;(2):CD003120.

82. Wu Y et al. “Ginkgo biloba extract improves coronary blood flow in patients with coronary artery disease: role of endothelium-dependent vasodilation.” Planta Med. 2007 Jun;73(7):624-8. Epub 2007 Jun 13.

83. Li XX et al. “[Protective effects of extract of Ginkgo biloba on vascular endothelial dysfunction induced by AGEs-BSA in vivo.]” Zhong Yao Cai. 2007 Sep;30(9):1109-13.

84. Liu C, Qian G, Liu H. “[Experimental study on suppressive effect of ginkgo extract on adhesion of vascular endothelial cell to monocyte induced by minimally modified low density lipoprotein.]” Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Dec;20(12):917-9.

85. Muir AH et al. “The use of Ginkgo biloba in Raynaud’s disease: a double-blind placebo-controlled trial.” Cardiovasc Med. 2002;7:265-67.

86. Carini M et al. “Complexation of Ginkgo biloba extract with phosphatidylcholine improves cardioprotective activity and increases the plasma antioxidant capacity in the rat.” Planta Med. 2001;67:236-30.

87. Pittler MH, Guo R, Ernst E. “Hawthorn extract for treating chronic heart failure.” Cochrane Database Syst Rev. 2008;1:CD005312.

88. Chen ZY et al. “Endothelium-dependent relaxation induced by hawthorn extract in rat mesenteric artery.” Life Sci. 1998;63(22):1983-91.

89. Lan WJ, Ge YK, Zheng XX. “Regulative effects of hawthorn leave flavonoids on cytotoxicity, NO and Ca2+ in hypoxia-treated human umbilical vein endothelial cells.” Space Med Med Eng (Beijing). 2005 Jun;18(3):157-60.

90. Corder R et al. “The procyanidin-induced pseudo laminar shear stress response: a new concept for the reversal of endothelial dysfunction.” Clin Sci (Lond). 2004 Nov;107(5):513-7.

91. Lissin LW et al. “Isoflavones improve vascular reactivity in post-menopausal women with hypercholesterolemia.” Vasc Med. 2004 Feb;9(1):26-30.

92. Hallund J et al. “Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women.” Br J Nutr. 2006 Jun;95(6):1120-6.

93. Steinberg FM et al. “Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women.” Am J Clin Nutr. 2003 Jul;78(1):123-30.

94. Colacurci N et al. “Effects of soy isoflavones on endothelial function in healthy postmenopausal women.” Menopause. 2005 May-Jun;12(3):299-307.

95. Liu D, Homan LL, Dillon JS. “Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5'-monophosphate-dependent mechanism.” Endocrinology. 2004 Dec;145(12):5532-9. Epub 2004 Aug 19.

96. Nakaya M, Tachibana H, Yamada K. “Isoflavone genistein and daidzein up-regulate LPS-induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells.” Biochem Pharmacol. 2005 Dec 19;71(1-2):108-14. Epub 2005 Nov 3.

97. Fujita M et al. "Characterization of Nattokinase-degraded products from human fibrinogen or cross-linked fibrin." Fibrinolysis. 9:157-164, 1995.

98. Lowe GD et al. "Blood viscosity and risk of cardiovascular events." Br J Haematol. 96:168-173, 1997.

99. Pais E et al. “Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity.” Clin Hemorheol Microcirc. 2006;35(1-2):139-42.

100. Suzuki Y et al. “Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery.” Life Sci. 2003 Jul 25;73(10):1289-98.

101. Cesarone MR et al. “Prevention of venous thrombosis in long-haul flights with Flite Tabs: the LONFLIT-FLITE randomized, controlled trial.” Angiology. 2003 Sep-Oct;54(5):531-9.

102. Maurer HR. “Bromelain: biochemistry, pharmacology and medical use.” Cell Mol Life Sci. 2001 Aug;58(9):1234-45.

103. Gläser D, Hilberg T. “The influence of bromelain on platelet count and platelet activity in vitro.” Platelets. 2006 Feb;17(1):37-41.

104. Metzig C et al. “Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo.” In Vivo. 1999 Jan-Feb;13(1):7-12.

105. Sipola M et al. “Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats.” Life Sci. 2002 Aug 2;71(11):1245-53.

106. Sipola M et al. “Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats.” J Physiol Pharmacol. 2001 Dec;52(4 Pt 2):745-54.

107. Nurminen ML et al. “Alpha-lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats.” Life Sci. 2000;66(16):1535-43.

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