Mechanism Behind Possible Anti-Carcinogenic Effect ofVitamin E Discovered

Mechanism Behind Possible Anti-Carcinogenic Effect of Vitamin E Discovered

TORONTO--Recent research out of Sunnybrook and Women's College Health Science Centre has provided a theoretical basis to explain the chemopreventive effect of vitamin E. According to a study published in the October issue of The Journal of Urology (168, 4:1578-82, 2002) (www.jurology.com), vitamin E up-regulated p27, a regulatory protein, which thereby stops cancer cell cycling in vitro. Researchers incubated human prostate cancer cells with and without vitamin E (as alpha-tocopherol succinate at a dose of 20 mcg/ml). The presence of vitamin E dramatically reduced cell cycle progression, and induced a three-fold increase in p27 expression.

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